$100 discount coupon for 2005 PTC course - see details below

PTC Tip of the Month
Avoid Overdrying PTC Reactions

US Patent 6,790,981 (Mueller et al. 14-Sep-2004) is a compelling example which notes that even when working with water-sensitive compounds in PTC systems, it is important to avoid overdrying when screening for optimal conditions. In this application, the inventors reacted sodium phenolsulfonate (SPS) with nonanoyl chloride using diethyleneglycol-dimethylether as the complexant phase-transfer catalyst (likely acts as an open crown ether complexing with the sodium) and Isopar G as solvent. When the system is overdried, a yield of 45% is obtained, whereas a 95% yield is obtained with more optimal drying of "lower quality" SPS! An older but good PTC version of this reaction is shown in the PTC Reaction of the Month below.

Please forward this PTC Tip of the Month to your colleagues and encourage them to subscribe

PTC Training
2-Day PTC Course in Newark and Chicago

The 2-day course "Practical Phase-Transfer Catalysis" will be conducted in Newark, New Jersey on Feb 15-16, 2005 and in Chicago on April 12-13, 2005 (click on link for registration). More than 530 chemists, engineers and managers at nearly 100 companies have participated in this highly rated course from 1996 to 2004. Click here for details and agenda  
$100 discount coupon: To obtain a personal non-transferable coupon for a $100 discount for the 2005 course in Newark or Chicago, send the following information by E-mail or fax (+1 856-222-1124) to Marc Halpern by October 29, 2004. Write "Request 2005 PTC Course Coupon" as the subject. 
Preferred location for 2-day PTC Course (choose one): Newark - Feb 15-16, 2005 or Chicago Apr 12-13, 2005

One coupon per customer. Coupons cannot be combined. Coupon has no cash value. Coupon is personal and non-transferable. Requesting the coupon does not constitute registration or obligation attend either course. The price for the course without the coupon is $1,295 per participant (regular registration) and $1,195 per participant for early registration. With the coupon, the price for the course will be $1,195 per participant (regular registration) and $1,095 per participant for early registration. Click on links above for registration deadlines.  

In-House Course: Practical Phase-Transfer Catalysis" can also be conducted at your company anytime (North America, Europe or Japan) as a private in-house course. To set a date, contact us by E-mail, telephone (+1 856-222-1146) or fax (+1 856-222-1124).

PTC Reaction of the Month
Phenol O-Acylation Using Acid Chloride

This patent describes the PTC O-acylation shown below. The inventors note that PTC enhances the rate of reaction for the preparation of alkanoyloxybenzenesulfonate salts of high purity. In addition, the process uses lower temperatures than for similar non-PTC processes, and "the loadings of acid chloride required to carry out the reaction are lower, which, in combination, renders the process very economical." Dumas, D.; Subramanyam, V. (E. I. Du Pont de Nemours) US Patent 5,069,828, 03-Dec-1991

If you can't see the structures, click HERE

Phase-Transfer Catalyst of the Month

This inexpensive phase-transfer catalyst works as a complexant and can be extremely effective and useful in applications such as that shown in the PTC Tip of the Month above. This catalyst is inert under most PTC conditions (basic and neutral) and has a boiling point attractive for easy separation and recovery. 
It is not always obvious which PTC applications will be catalyzed by glymes. However, it is usually worthwhile to screen these catalyst before setting the process in stone. 

Availability, Samples and Quotes

Request samples and quotes from: 
Clariant (click on link)

Other Phase-Transfer Catalysts:
PTC Supplier Directory:
choose from a dozen suppliers & 80 PT catalysts and ask for free samples & quotes.

1-Hour PTC Webinar  in 2005

PTC Communications is considering conducting a 1-hour webinar (seminar over the web) in 2005 on a PTC topic(s) of value to our customers. Your input is required to justify this event or series. A PTC Training survey will be sent to you shortly. In the meantime, feel free to suggest specific PTC topics by contacting Marc Halpern by
E-mail or telephone (+1 856-222-1146) or fax (+1 856-222-1124). A sponsor has been identified and will absorb almost 100% of the costs including logistics.  In case you may be concerned, the webinar will be technical and not a sales pitch.

New PTC Service
PTC Option Go/No-Go Consultation

Provide a quick and cost-effective key decision aid during initial project planning, whether to pursue evaluation of phase-transfer catalysis as an option to achieve success or breakthrough performance for an organic reaction/process, consisting of uniquely qualified expert opinion and supported by 28 years of PTC experience and documented evidence.

Benefit & When To Use
Can be crucial to achieve highly effective R&D for organic chemical reactions/processes during:

PTC Organics will deliver a written confidential "PTC Option Opinion" for a specific organic reaction which will include

Initiating the Project
To initiate project or obtain attractive pricing for 2005 budget planning, contact Marc Halpern at tel +1 856-222-1146, fax: +1 856-222-1124 or E-mail.

Inexpensive patent attorney (United States) familiar with Phase-Transfer Catalysis, organic chemistry and biochemistry. Contact Mannie Morgenstern by E-mail or at telephone 818-788-5531 (California). 

Free Subscription to Chemical Pilot Magazine - Chemical Pilot Magazine is a highly focused tool to help you understand the factors that drive success in the critical stage between idea creation and commercialization in the chemical industry. Each quarterly issue has five sections: emerging technologies, protecting your technology, staying competitive, education, government and policy. Register for your free subscription or send ideas for articles to editor@chemicalpilot.com.


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Before performing any PTC reactions read this important message
Organic chemical reactions are inherently dangerous. Moreover, phase-transfer catalysis may provide rate and other enhancements which can intensify associated hazards. Under no circumstances should anyone perform any procedure on any scale based in whole or in part on any of the contents of this information provided here before thoroughly establishing safe operating procedures and performing a full and competent hazardous operations analysis with the participation of qualified technical personal trained in chemical, engineering, safety, industrial hygiene and environmental disciplines and sciences.

The list of PTC Tip of the Month subscribers will not be sold, rented or transferred and will be used only by PTC Communications, Inc. and PTC Organics, Inc. to provide information related to Phase-Transfer Catalysis. PTC Communications, Inc. reserves the right to distribute the PTC Tip of the Month to selected industrial chemists, engineers and managers.

PTC Tip of the Month #25 - October 2004
Copyright 2004 PTC Communications, Inc.

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