PTC Supplier Directory | PTC Technology & Information Center | PTC Course | PTC Process Screening | Unsubscribe (below)
Tip of the Month - Save Borohydride Cost Using PTC
Want to save money by using less borohydride? It turns out that PTC-borohydride reductions use less borohydride than classical ethanolic borohydride because borohydride is more stable in water than in ethanol. For example, a 98% yield of Terfenadine was achieved using only 4 mole% excess NaBH4 with PTC instead of 30 mole% excess using ethanolic NaBH4 without PTC (Magni, A. [Gruppo Lepetit] 1989 Eur. Pat. EP 0 346 765). Learn more about PTC borohydride reduction at the 2-Day Practical PTC course in New Jersey in May 2003. TIP: You can quickly screen your PTC-borohydride idea by using the newly available tetrabutyl ammonium borohydride salt available from GFS. Contact information can be found on the Phase-Transfer Catalyst Supplier Directory launched last month.
Please forward the PTC Tip of the Month to your industrial colleagues
PTC 2-Day Course - registration deadline soon
Register for the 2-day course "Practical Phase-Transfer Catalysis" to be held in New Jersey on May 6-7, 2003 (click for agenda) or train your whole department on-site, in-house. A veteran pharmaceutical process chemist wrote (Apr 2002 course): "Best training in my 18 years in industry." He also reported scaling up a new PTC process in November 2002. 87 companies have participated in 28 public and private in-house courses in the US and Europe. Registration is now open. Registration Deadline: April 1, 2003 (or March 1, if you need an invoice).
PTC Reaction of the Month - Chiral Borohydride Reduction & Collaboration Opportunity
Professor Tom Pochapsky at Brandeis was the first innovator of the chiral anthracenylmethyl cinchona PTC quats (represented as Q*+ Cl- in the figure). US Patent Application 20020115896 (Aug 2002) describes the chiral borohydride reduction shown below. Pharmaceutical and agrochemical R&D scientists and managers are encouraged to contact Professor Pochapsky to explore collaboration on chiral PTC through: Sheryl M. Greenberg, Ph.D., Office of Intellectual Property & Technology Transfer, Brandeis University MS115, 415 South Street, Waltham, MA 02454-9110, Tel: 781-736-2128, Fax: 781-736-2168, E-mail: firstname.lastname@example.org.
- "Best of Industrial PTC"
We appreciate your interest in PTC Organics' services for screening, developing and commercializing high-performance low-cost PTC processes. We will send you a gift of appreciation: the CD-ROM "The Best of Industrial Phase-Transfer Catalysis" if you call Marc Halpern at +1 856-222-1146 or Contact PTC Organics and write in the "Comments" section "please send me the CD-ROM Best of Industrial PTC" by February 2003. The CD's will be sent in March 2003. Limit: one CD per person and you must provide a valid industrial address.
PTC Supplier Directory - very useful resource
Very useful resource: Phase-Transfer Catalyst Supplier Directory. Free and very easy to use (2 clicks). One click to find multiple suppliers from around the world for > 75 phase-transfer catalysts, including quaternary ammonium & phosphonium quats, polyethylene glycols and their ethers, crown ethers, chiral PTC's, ionic liquids and high-temperature phase-transfer catalysts. The second click gives you full supplier contact information, website and E-mail useful for requesting samples and requesting competitive quotes directly from multiple suppliers.
Informex 2003 - PTC Organics Exhibitor Showcase
Contact PTC Organics or call Marc Halpern at +1 856-222-1146 to arrange a meeting at Informex 2003 booth 1611 to discuss how we can help you screen, develop and commercialize high-performance low-cost PTC processes. PTC Organics will present at the Exhibitor Showcase at 2:20 pm on Tuesday, February 25.
PTC Process Screening
PTC Organics now offers PTC Process Screening for rapid and highly effective evaluation of breakthrough phase-transfer catalysis processes. As the world leader in industrial phase-transfer catalysis, PTC Organics develops high-performance low-cost PTC processes. Contact Marc Halpern at PTC Organics by E-mail, website, telephone (+1 856-222-1146) or fax (+1 856-222-1124). Not sure if PTC can help improve performance? Just call and let's talk about PTC. Click here for 41 high-performance PTC reaction categories and benefits (allow 60 sec for downloading pdf file).
The PTC Technology & Information Center
Download back issues or individual articles from "Industrial Phase-Transfer Catalysis," "The PTC Tip of the Month," "PTC Forum & Message Board" (active since 1996) and much more.
To stop receiving the "PTC Tip of the Month," hit "Reply" and type "Remove" in the Subject line. To receive the "PTC Tip of the Month," Contact Us and type "Subscribe to Tip" in the Comments.
The list of PTC Tip of the Month subscribers will not be sold and will be used only by PTC Communications, Inc. and PTC Organics, Inc. to provide information related to Phase-Transfer Catalysis. PTC Communications, Inc. reserves the right to distribute Tip of the Month to selected industrial chemists, engineers and managers.
PTC Tip of the Month #5
Copyright 2003 PTC Communications, Inc.